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Hisamitsu Hayashi Selected Research

4-phenylbutyric acid (Buphenyl)

12/2021Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders.
11/2019Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis.
6/2016Effects of 4-phenylbutyrate therapy in a preterm infant with cholestasis and liver fibrosis.
2/2016Successful treatment with 4-phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption.
7/2014Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1.
5/2014Improved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2.
1/2014[Development of new therapeutic strategy for transporter-related diseases].
6/2012AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.
5/20124-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
9/2010Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).
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Hisamitsu Hayashi Research Topics

Disease

10Cholestasis
04/2022 - 09/2006
10progressive familial intrahepatic 1 Cholestasis
01/2021 - 04/2005
8Intrahepatic Cholestasis
12/2021 - 09/2010
6Inborn Urea Cycle Disorders
12/2021 - 01/2009
3Liver Cirrhosis (Hepatic Cirrhosis)
06/2022 - 06/2016
3Meniere Disease (Menieres Disease)
11/2021 - 01/2010
3Ornithine Carbamoyltransferase Deficiency Disease
06/2016 - 05/2012
3Pruritus (Itching)
02/2016 - 05/2014
2Jaundice (Icterus)
06/2022 - 06/2016
2Liver Failure
04/2022 - 01/2014
2Sensorineural Hearing Loss
01/2022 - 12/2019
2Vertigo (Positional Vertigo)
11/2021 - 01/2010
2Liver Diseases (Liver Disease)
01/2021 - 06/2016
2Hearing Loss (Hearing Impairment)
01/2021 - 12/2019
2Pain (Aches)
02/2020 - 12/2019
2Hepatocellular Carcinoma (Hepatoma)
12/2016 - 03/2014
1Rare Diseases (Rare Disease)
06/2022
1Carcinogenesis
04/2022
1Atrophy
01/2021
1End Stage Liver Disease
01/2021
1Headache (Headaches)
02/2020
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
02/2020
1Brain Abscess (Abscess, Brain)
02/2020
1Fatigue
12/2019
1Bilateral Hearing Loss
12/2019
1Inflammation (Inflammations)
12/2019
1Wells syndrome
12/2019
1Rheumatic Fever (Acute Articular Rheumatism)
12/2019
1Small Cell Carcinoma
01/2017
1Ganglion Cysts (Ganglion)
01/2017
1Brain Injuries (Brain Injury)
12/2016
1Failure to Thrive
06/2016
1Hyperbilirubinemia
12/2015
1Orthostatic Hypotension (Postural Hypotension)
01/2013
1Dizziness (Lightheadedness)
01/2013
1Lymphatic Metastasis
10/2012
1Tinnitus
05/2012
1Semicircular Canal Dehiscence
06/2011
1Atherosclerosis
04/2011
1Hyperammonemia
06/2010
1Breast Neoplasms (Breast Cancer)
05/2008

Drug/Important Bio-Agent (IBA)

12Member 11 Subfamily B ATP Binding Cassette TransporterIBA
06/2020 - 04/2005
114-phenylbutyric acid (Buphenyl)FDA Link
12/2021 - 06/2010
8Bile Acids and Salts (Bile Acids)IBA
06/2022 - 09/2006
8Pharmaceutical PreparationsIBA
11/2019 - 01/2009
3Therapeutic UsesIBA
06/2016 - 05/2012
2Hydrocortisone (Cortisol)FDA LinkGeneric
01/2021 - 12/2011
2Peptides (Polypeptides)IBA
12/2015 - 09/2006
2Proteins (Proteins, Gene)FDA Link
07/2013 - 05/2008
2Hormones (Hormone)IBA
05/2012 - 12/2011
1Aldo-Keto ReductasesIBA
06/2022
1EnzymesIBA
06/2022
1LipidsIBA
06/2022
1Zonula Occludens-2 ProteinIBA
04/2022
1CytokinesIBA
01/2022
1Biomarkers (Surrogate Marker)IBA
01/2022
1Fibrinogen (Factor I)FDA Link
01/2022
1SteroidsIBA
11/2021
1Dehydroepiandrosterone (DHEA)IBA
01/2021
1Adenosine Triphosphatases (ATPase)IBA
01/2021
1AmmoniaIBA
01/2021
1Phospholipids (Phosphatides)FDA LinkGeneric
01/2021
1Monoclonal AntibodiesIBA
12/2019
1InterleukinsIBA
12/2019
1Methotrexate (Mexate)FDA LinkGeneric
12/2019
1canakinumabFDA Link
12/2019
1Prednisolone (Predate)FDA LinkGeneric
12/2019
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
01/2017
1Apolipoprotein A-I (Apolipoprotein A1)IBA
12/2016
1CholesterolIBA
12/2016
1Ursodeoxycholic Acid (Urso)FDA LinkGeneric
06/2016
1BilirubinIBA
02/2016
1AnionsIBA
12/2015
1Chlorpromazine (Thorazine)FDA Link
03/2014
1ClathrinIBA
03/2014
1XenobioticsIBA
07/2013
1hydroxide ionIBA
01/2013
1GW 4064IBA
06/2012
1PowdersIBA
05/2012
1calcium phosphateIBA
06/2011
1CalpainIBA
04/2011
1Urea (Carbamide)FDA LinkGeneric
06/2010
1TransferasesIBA
06/2010
1Arginine Vasopressin (Argipressin)IBA
01/2010
1Vasopressins (Vasopressin)IBA
01/2010

Therapy/Procedure

7Therapeutics
11/2021 - 01/2014
3Liver Transplantation
06/2022 - 01/2014
2Conservative Treatment
11/2021 - 01/2010
1Oral Administration
12/2021
1Injections
11/2021
1Artificial Respiration (Mechanical Ventilation)
02/2020
1Cochlear Implants (Cochlear Implant)
12/2019
1Cochlear Implantation
12/2019
1Radiotherapy
01/2017
1Electrodes (Electrode)
01/2017
1Drug Therapy (Chemotherapy)
01/2017
1Stem Cell Transplantation
12/2016
1Lymph Node Excision (Lymph Node Dissection)
10/2012
1Complementary Therapies (Alternative Medicine)
05/2012
1Intravenous Administration
06/2010